منابع مشابه
Regulatory mechanisms for HBV replication
Hepatitis B virus (HBV) is one of the smallest enveloped DNA viruses and infects more than 350 million people worldwide. HBV infection causes acute and chronic hepatitis, and is one of the major causes of cirrhosis and hepatocellular carcinoma. Currently available therapies can achieve viral suppression, but not termination of HBV infection. HBV replicates its genome via an RNA intermediate in ...
متن کاملHBV structural biology and replication
Hepatitis B virus (HBV) infection is a global human health problem, with an estimated 350 million people having chronic hepatitis B (CHB) infection worldwide. The majority of infections acquired during adulthood are resolved without intervention; however, infections acquired at birth or during early childhood have a 90% chance of progressing to CHB, leading to a host of adverse effects on the l...
متن کاملSelective inhibitors of picornavirus replication.
Picornaviruses cover a large family of pathogens that have a major impact on human but also on veterinary health. Although most infections in man subside mildly or asymptomatically, picornaviruses can also be responsible for severe, potentially life-threatening disease. To date, no therapy has been approved for the treatment of picornavirus infections. However, efforts to develop an antiviral t...
متن کاملMicroRNA-141 Represses HBV Replication by Targeting PPARA
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression primarily at the post-transcriptional level and play critical roles in a variety of physiological and pathological processes. In this report, miR-141 was identified to repress HBV expression by screening a small miRNA expressing library and synthetic miR-141 mimics could also significantly suppress HBV expression and rep...
متن کاملDoxorubicin activates hepatitis B virus (HBV) replication in HBV-harboring hepatoblastoma cells. A possible novel mechanism of HBV reactivation in HBV carriers receiving systemic chemotherapy.
BACKGROUND Reactivation of HBV replication is a clinically significant complication in HBV(+) patients receiving chemotherapy. We recently found that nearly half of the HBV reactivation in lymphoma patients occurred within 2 weeks of the first dose of chemotherapy. We hypothesized that mechanisms other than immunosuppression, such as direct stimulation of HBV replication by anticancer drugs, mi...
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ژورنال
عنوان ژورنال: Antiviral Research
سال: 2020
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2020.104815